Susceptibility to childhood onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of five genetic risk variants

نویسندگان

  • Sampath Prahalad
  • Milton Brown
  • Susan D Thompson
  • Michael Zwick
  • David Cutler
  • Lori A Ponder
  • Jennifer Prozonic
  • Sheila Angeles-Han
  • Larry B Vogler
  • Christine W Kennedy
  • Carol A Wallace
  • Carol Wise
  • Marilynn G Punaro
  • Ann M Reed
  • Jane L Park
  • Elizabeth D Mellins
  • John F Bohnsack
  • David N Glass
چکیده

Susceptibility to childhood onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of five genetic risk variants Sampath Prahalad, Milton Brown, Susan D Thompson, Michael Zwick, David Cutler, Lori A Ponder, Jennifer Prozonic, Sheila Angeles-Han, Larry B Vogler, Christine W Kennedy, Carol A Wallace, Carol Wise, Marilynn G Punaro, Ann M Reed, Jane L Park, Elizabeth D Mellins, John F Bohnsack, David N Glass

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of IL-10 rs1800896 (-1082 G/A) gene polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran

Background and objectives: Rheumatoid arthritis (RA) is a complex and systemic inflammatory disease in which the immune response is disturbed. Single nucleotide polymorphisms (SNPs) in the promoter regions of regulatory cytokines including interleukin-10 (IL-10) may lead to exacerbated immune response and increased risk of RA. Here, we aimed to assess the association of IL-10 -1082 (G/A) (rs180...

متن کامل

CD226 rs763361 (Gly307Ser) Polymorphism Is Associated with Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. Methods: This case-control study was carried out on 100 patients with RA and 104 healthy su...

متن کامل

Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran

Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA ...

متن کامل

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk

BACKGROUND There is currently great interest in the incorporation of genetic susceptibility loci into screening models to identify individuals at high risk of disease. Here, we present the first risk prediction model including all 46 known genetic loci associated with rheumatoid arthritis (RA). METHODS A weighted genetic risk score (wGRS) was created using 45 RA non-human leucocyte antigen (H...

متن کامل

Genetic Risk Score Predicting Risk of Rheumatoid Arthritis Phenotypes and Age of Symptom Onset

BACKGROUND Cumulative genetic profiles can help identify individuals at high-risk for developing RA. We examined the impact of 39 validated genetic risk alleles on the risk of RA phenotypes characterized by serologic and erosive status. METHODS/PRINCIPAL FINDINGS We evaluated single nucleotide polymorphisms at 31 validated RA risk loci and 8 Human Leukocyte Antigen alleles among 542 Caucasian...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2012